TRPV1

TRPV1
Identifikatori
Aliasi	TRPV1
Vanjski ID-jevi	OMIM: 602076 MGI: 1341787 HomoloGene: 12920 GeneCards: TRPV1
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17p13.2 Početak 3,565,444 bp[1] Kraj 3,609,411 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 B4|11 45.25 cM Početak 73,125,118 bp[2] Kraj 73,152,068 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • ion channel activity • phosphoprotein binding • ATP binding • cation transmembrane transporter activity • cation channel activity • ligand-gated ion channel activity • calcium-release channel activity • temperature-gated ion channel activity • vezivanje identičnih proteina • chloride channel regulator activity • transmembrane signaling receptor activity • excitatory extracellular ligand-gated ion channel activity • calcium channel activity • extracellular ligand-gated ion channel activity • phosphatidylinositol binding • vezivanje iona metala • calmodulin binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • integral component of membrane • postsynaptic membrane • projekcija ćelije • membrana • ćelijska membrana • sinapsa • međućelijske veze • dendritic spine membrane • citosol • neuronal cell body • intrinsic component of plasma membrane • dendrit • external side of plasma membrane • neuron projection • integral component of plasma membrane • mitohondrija Biološki proces • ion transport • chemosensory behavior • cell surface receptor signaling pathway • calcium ion transmembrane transport • thermoception • calcium ion transport • inflammatory response • transmembrane transport • release of sequestered calcium ion into cytosol • GO:1901227 negative regulation of transcription by RNA polymerase II • diet induced thermogenesis • detection of chemical stimulus involved in sensory perception of pain • microglial cell activation • cellular response to growth factor stimulus • positive regulation of gastric acid secretion • response to peptide hormone • cellular response to nerve growth factor stimulus • positive regulation of nitric oxide biosynthetic process • negative regulation of establishment of blood-brain barrier • lipid metabolism • temperature homeostasis • response to heat • cellular response to temperature stimulus • positive regulation of cytosolic calcium ion concentration • peptide secretion • detection of temperature stimulus involved in sensory perception of pain • sensory perception of mechanical stimulus • smooth muscle contraction involved in micturition • behavioral response to pain • response to pain • cellular response to alkaloid • cellular response to cytokine stimulus • fever generation • detection of temperature stimulus involved in thermoception • positive regulation of apoptotic process • urinary bladder smooth muscle contraction • glutamate secretion • Nocicepcija • cellular response to tumor necrosis factor • cellular response to ATP • ion transmembrane transport • response to pH • response to organonitrogen compound • cellular response to heat • protein homotetramerization • excitatory postsynaptic potential • cellular response to acidic pH • response to capsazepine • calcium ion import across plasma membrane • negative regulation of systemic arterial blood pressure • negative regulation of heart rate • negative regulation of mitochondrial membrane potential Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7442	193034
Ensembl	ENSG00000196689	ENSMUSG00000005952
UniProt	Q8NER1	Q704Y3
RefSeq (mRNK)	NM_018727 NM_080704 NM_080705 NM_080706	NM_001001445
RefSeq (bjelančevina)	NP_061197 NP_542435 NP_542436 NP_542437	NP_001001445
Lokacija (UCSC)	Chr 17: 3.57 – 3.61 Mb	Chr 11: 73.13 – 73.15 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Član 1 podporodice V prolaznog recepcijskog potencijala kationskog kanala (TrpV1), poznat i kao kapsaicinski receptor i vaniloidni receptor 1, je protein koji je kod ljudi kodiran genom TRPV1. To je bio prvi izolirani član prolaznih receptora potencijalnih proteinskih vaniloidnih receptora, koji su pak potporodica potencijalne proteinske skupine prolaznih receptora.^[5][6] Ovaj protein je član grupe TRPV, privremenih potencijalnih receptora porodice ionskih kanala.^[7]

Funkcija TRPV1 je otkrivanje i regulacija tjelesne temperature. Pored toga, TRPV1 pruža upareni osjećaj vrućine i bola (nocicepcija). U primarnom aferentnom senzornim neuronima, sarađuje sa TRPA1 ^[8][9] (hemijski iritantni receptor) da posreduje u otkrivanju štetnih podražaja iz okoline.^[10]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 839 aminokiselina, a molekulska težina 94.956 Da.^[11]

Simboli

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000196689 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000005952 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (oktobar 1997). "The capsaicin receptor: a heat-activated ion channel in the pain pathway". Nature. 389 (6653): 816–24. Bibcode:1997Natur.389..816C. doi:10.1038/39807. PMID 9349813. S2CID 7970319.
6. ^ Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA (august 2001). "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants". Genomics. 76 (1–3): 14–20. doi:10.1006/geno.2001.6582. PMID 11549313.
7. ^ Clapham DE, Julius D, Montell C, Schultz G (decembar 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
8. ^ Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (april 2015). "Structure of the TRPA1 ion channel suggests regulatory mechanisms". Nature. 520 (7548): 511–7. Bibcode:2015Natur.520..511P. doi:10.1038/nature14367. PMC 4409540. PMID 25855297.
9. ^ Zhao, Jianhua; Lin King, John V.; Paulsen, Candice E.; Cheng, Yifan; Julius, David (8. 7. 2020). "Irritant-evoked activation and calcium modulation of the TRPA1 receptor". Nature (jezik: engleski). 585 (7823): 141–145. doi:10.1038/s41586-020-2480-9. ISSN 0028-0836. PMC 7483980. PMID 32641835. S2CID 220407248.
10. ^ Basbaum AI, Bautista DM, Scherrer G, Julius D (oktobar 2009). "Cellular and molecular mechanisms of pain". Cell. 139 (2): 267–84. doi:10.1016/j.cell.2009.09.028. PMC 2852643. PMID 19837031.
11. ^ "UniProt, Q8NER1". Pristupljeno 14. 6. 2021.